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Lymphedema & Phlebolymphedema

Lymphedema & Phlebolymphedema

Understanding and Management

Swelling in an arm or leg caused by a lymphatic system blockage. This may be accompanied by pain or discomfort. Exercise, wrapping, massage, and compression can help. The vein center at Phoenix Heart is staffed with expert physicians who have helped many patients with treatment. To schedule an appointment, use the online booking feature or call one of the o
a phlebologist examines a patient with varicose veins on his leg

Lymphedema & Phlebolymphedema Q & A

What is Lymphedema?

Lymphedema refers to tissue swelling caused by an accumulation of protein-rich fluid that’s usually drained through the body’s lymphatic system. It most commonly affects the arms or legs, but can also occur in the chest wall, abdomen, neck and genitals. Lymph nodes are an important part of your lymphatic system.

What causes Lymphedema?

The lymphatic system is a network of vessels that carry protein-rich lymph fluid throughout the body. It’s part of your immune system. Lymph nodes act as filters and contain cells that fight infection and cancer.

The lymph fluid is pushed through the lymph vessels by muscle contractions as you move through the tasks of your day and small pumps in the wall of the lymph vessels. Lymphedema occurs when the lymph vessels are not able to adequately drain lymph fluid, usually from an arm or leg.

The most common causes of lymphedema include:

  • Cancer
    If cancer cells block lymph vessels, lymphedema may result. For instance, a tumor growing near a lymph node or lymph vessel could enlarge enough to block the flow of the lymph fluid.
  • Radiation Treatment for Cancer
    Radiation can cause scarring and inflammation of lymph nodes or lymph vessels.
  • Surgery
    In cancer surgery, lymph nodes are often removed to see if the disease has spread. However, this doesn’t always result in lymphedema.
  • Parasites
    In developing countries in the tropics, the most common cause of lymphedema is infection with threadlike worms that clog the lymph nodes.
Less commonly, lymphedema results from inherited conditions in which the lymphatic system doesn’t develop properly.

What symptoms develop due to Lymphedema?

Signs and symptoms include:
physical therapist treating a patient who has lymphedema

How is Lymphedema Treated?

There’s no cure for lymphedema. Treatment focuses on reducing the swelling and preventing complications.
  • Medications:
    Lymphedema greatly increases the risk of skin infections (cellulitis). Your doctor may prescribe antibiotics for you to keep on hand so that you can start taking them immediately once symptoms appear.
  • Therapy:
    Specialized lymphedema therapists can teach you about techniques and equipment that can help reduce lymphedema swelling. Examples include:

Surgical and Other Procedures

Surgical treatment for lymphedema may include:

Informational PDFs


What is Phlebolymphedema?

Phlebolymphedema is the most common form of lymphedema in the Western world. It is a combined lymphatic and vascular condition that causes inflammation and lymphedema in the feet and lower legs. It begins with chronic venous insufficiency (CVI) in which the one-way valves in the veins of the lower legs lose the ability to completely close.


While most of the blood normally moves upwards back to the heart, some blood flows backwards because of the faulty valves.

This backward flow, called venous reflux, strains the vein walls and blood plasma leaks into the interstitial space. This produces swelling in the feet, ankles, and calves. The lymphatic system works as a safety valve to move the excess fluid out of the legs.

CVI usually affects both legs. At first, CVI symptoms might show up as swollen ankles at the end of the day that reduce overnight when legs are horizontal in bed. As CVI becomes more advanced, it causes lymphatic overload and becomes phlebolymphedema.

What causes Chronic Venous Insufficiency (CVI) and Phlebolymphedema?

There are many contributing factors to CVI. These include family history, pregnancy, inflamed veins, blood clots, trauma, or damage to legs from surgery. Lifestyle factors such as smoking, lack of exercise, prolonged hours of sitting or standing, or being overweight can also impact CVI. Diagnostic testing for CVI includes ultrasound imaging, ankle-brachial index, and various types of venograms. Medical procedures to treat varicose veins may be recommended.
a phlebologist does an ultrasound of the veins of a patient with varicose veins.

What symptoms develop due to Phlebolymphedema?

These ongoing symptoms of redness can often be confused with cellulitis infections, which we’ll address a little later in this article.

How is Phlebolymphedema Treated?

It is important for patients to have a comprehensive treatment program to reduce swelling and prevent progression of phlebolymphedema. Patients with phlebolymphedema benefit from treatment by wound care specialists and by certified lymphedema therapists.

Complete decongestive treatment is administered by a certified lymphedema therapist. This treatment consists of manual lymphatic drainage, compressive wraps and garments, skin care, and exercise. Conservative treatment consists of elevation, exercise, and compression.

Manual Lymphatic Drainage

Manual lymphatic drainage is a specialized type of medical massage that increases vascular and lymphatic circulation, and decongests swelling. Modification may be necessary for patient comfort if there is a painful wound present.

Areas of heavy fibrotic damage require more pressure against the surface of dense tissue in order to effectively move swelling that is trapped inside and underneath. Applying compression following manual lymphatic drainage is important to maintaining the reduction of swelling.


Wearing compression on the feet and legs helps swelling in a number of ways. External pressure that compresses against the veins improves their ability to move blood upward. This pressure also helps the lymph system. Wearing compression during exercise increases the effectiveness of the calf muscle pump.

Layered bandages or Velcro compression wraps are used in the initial reduction phase of treatment for very swollen feet and legs. They are also used for those with wounds, or for those who have difficulty putting on tight compression stockings. Wound clinics often use disposable compression systems such as zinc oxide wraps or multi-layered Coban wraps over dressings.

Gradient elastic stockings are the most common form of compression. They are generally used in the maintenance phase of treatment. Ready-made stockings have greater pressure at the ankle that lessens towards the top of the stocking, but less pressure in the foot. Custom stockings, wraps, or even tight lace up shoes provide extra compression required for stubborn foot swelling.

Skin care

First and foremost, all wounds must be treated. Because patients with phlebolymphedema are particularly vulnerable to wounds, prevention is critical. Dry, cracked, and itchy skin is common with phlebolymphedema. Moisturizing the skin heals these symptoms and builds a better barrier to avoid infections.


Walking utilizes the pumping action of the calf muscles to improve circulation in the veins and lymphatic vessels. Even seated exercise can be helpful. Doing ankle pumps for one minute can increase circulation in the legs for thirty minutes.

Ankle flexibility is crucial for proper calf muscle contraction. With tight ankles the calf muscles can’t fully contract as we see in those who “shuffle” when they walk. These people struggle more with swelling because the calf muscle pump is impaired. Those with paralysis or weakness of the lower legs are particularly vulnerable to swelling, however upper body exercise can help increase overall body circulation.

For those without wounds, aquatic exercise gives the benefit of water compression, making muscle contraction more effective. The deeper the water, the better because of greater compression at greater depth: For example, three feet of water creates 67.26 mmHg of pressure on the feet.

Deep abdominal breathing during exercise is also important to activate the diaphragmatic pump, which increases overall blood and lymph circulation.


Elevating the legs uses gravity to help move blood toward the heart. It also assists in the movement of lymph fluid to the lymph nodes in the back of the knees and the groin. These lymph nodes process and filter the fluid so it can eventually exit the body as urine.

Changing the position of the legs from time to time during the daytime is important. Many patients find it helpful to take an afternoon rest in bed with legs elevated on pillows. Some have difficulty lying flat on a bed because of back pain, sleep apnea, or other breathing issues, and prefer a recliner chair for sleep. However, most recliner chairs do not elevate legs horizontally to the level of the heart, leaving legs in a semi-dependent position. A hospital bed can help elevate both the upper body and the legs.

Patients need to be empowered with education to reduce the risks for swelling and to prevent cellulitis infections. Lifestyle changes make a significant difference with phlebolymphedema. Quitting smoking, losing weight, dietary changes, and regular exercise are all important.
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